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459 Despite promising results, further research is needed to confirm the efficacy, safety, and optimal dosage in HAPH treatment

PUFAs like linoleic and linolenic acid are specifically prone to attack by ROS like 1 O 2 and OH

DurantiGMaldiniMCrognaleDHornerKDimauroISabatiniSet al

Simultaneously, the SAPK/JNK pathway can suppress ferroportin expression, limiting the efflux of intracellular iron and further contributing to iron accumulation, thus promoting ferroptosis [129, 130]

In aging cells, FOXO4 normally binds to p53, preventing it from triggering programmed cell death

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